Abstract Search

ea0034p262 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014

Elevated cord leptin from low B12 mothers predicts birth weight

Antonysunil Adaikala , Vatish Manu , Lawson Alexander , Wood Catherine , Sivakumar Kavitha , Webster Craig , Anderson Neil , McTernan Philip , Tripathi Gyanendra , Saravanan Ponnusamy

Background: Vitamin B12 (B12) insufficiency is common in pregnancy and independently predicts insulin resistance (IR) in the offspring. B12 is an important key nutrient for epigenetic programming through regulating DNA methylation. Such B12 DNA methylation may influence leptin, a strong candidate for methylation, which could impact both insulin resistance (IR) and associated neonatal metabolic risk. Therefore, we hypothesize that leptin can be programmed by maternal B12 which ...

0 shares

ea0031p210 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013

Maternal B12 insufficiency predicts neonate's metabolic risk factors

Adaikalakoteswari Antonysunil , Alexander Lawson , Webster Craig , Wood Catherine , Anderson Neil , Sivakumar Kavitha , McTernan Philip , Tripathi Gyanendra , Vatish Manu , Saravanan Ponnusamy

Studies in India (vegetarian population) show that vitamin B12 insufficiency is common in pregnancy and independently predict adiposity and insulin resistance in the offspring. Epigenetic programming is postulated as, along with folic acid, B12 is crucial for DNA methylation. Therefore, we investigated whether maternal B12 levels in a non-vegetarian UK population predict metabolic risk of the offspring.Paired maternal venous and cord blood samples (n...

0 shares

Endocrine Abstracts

Elevated cord leptin from low B12 mothers predicts birth weight

Maternal B12 insufficiency predicts neonate's metabolic risk factors

BiosciAbstracts